Can you injure yourself beyond repair?

A few months ago I was weeding for a few hours. The next morning my right shoulder hurt with movement. My CIDP is mainly on my left leg, also bilateral hands and feet. I am right handed so I used my right hand and arm to weed. I originally wrote it off to under used muscles, but now I am wondering if my CIDP is causing the continued pain. Has anyone else experienced this? Also is infusion therapy a life long treatment?